Human KCNB1/Kv2.1 Recombinant Protein (N-His) (HC581012)

Name: Human KCNB1/Kv2.1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC581012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC581012
Description	Recombinant Human KCNB1/Kv2.1 Protein, N-His (HC581012) expressed in E. coli, spanning Glu19-Val186. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14721
Protein length	Glu19-Val186
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	22.29 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DRK1, Delayed rectifier potassium channel 1, KCNB1, Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, h-DRK1
Background	Potassium voltage-gated channel subfamily B member 1 is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. 1. Li, XN. et al. (2013) The Journal of pharmacology and experimental therapeutics 344, 407-16. PMID: 23161216 2. Shepard, AR. et al. (1999) The American journal of physiology 277, C412-24. PMID: 10484328 3. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340 4. Ikeda, SR. et al. (1992) Pflugers Archiv : European journal of physiology 422, 201-3. PMID: 1283219 5. Mederos Y Schnitzler, M. et al. (2009) The Journal of biological chemistry 284, 4695-704. PMID: 19074135 6. Bocksteins, E. et al. (2009) The Journal of biological chemistry 284, 31625-34. PMID: 19717558 7. Bocksteins, E. et al. (2014) PloS one 9, e98960. PMID: 24901643 8. Albrecht, B. et al. (1993) Receptors & channels 1, 99-110. PMID: 8081723 9. Sano, Y. et al. (2002) FEBS letters 512, 230-4. PMID: 11852086
Note	For research use only

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Datasheet

Human KCNB1/Kv2.1 Recombinant Protein (N-His).pdf

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Human KCNB1/Kv2.1 Recombinant Protein (N-His) (HC581012)

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