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Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014)

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Overview
Catalog No.HC581014
Description
Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014) is a rabbit polyclonal antibody detecting KCNB1. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KCNB1/Kv2.1 (Glu19-Val186).
Target DRK1, Delayed rectifier potassium channel 1, KCNB1, Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, h-DRK1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q14721
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Potassium voltage-gated channel subfamily B member 1 (KCNB1/Kv2.1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

1. Li, XN. et al. (2013) The Journal of pharmacology and experimental therapeutics 344, 407-16. PMID: 23161216
2. Shepard, AR. et al. (1999) The American journal of physiology 277, C412-24. PMID: 10484328
3. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340
4. Ikeda, SR. et al. (1992) Pflugers Archiv : European journal of physiology 422, 201-3. PMID: 1283219
5. Mederos Y Schnitzler, M. et al. (2009) The Journal of biological chemistry 284, 4695-704. PMID: 19074135
6. Bocksteins, E. et al. (2009) The Journal of biological chemistry 284, 31625-34. PMID: 19717558
7. Bocksteins, E. et al. (2014) PloS one 9, e98960. PMID: 24901643
8. Albrecht, B. et al. (1993) Receptors & channels 1, 99-110. PMID: 8081723
9. Sano, Y. et al. (2002) FEBS letters 512, 230-4. PMID: 11852086
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human KCNB1/Kv2.1 Polyclonal Antibody

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