Anti-Human KCNB1 Polyclonal Antibody (HC581014)

Name: Anti-Human KCNB1 Polyclonal Antibody
Brand: abinScience
SKU: HC581014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HC581014

Description

Anti-Human KCNB1/Kv2.1 Polyclonal Antibody (HC581014) is a rabbit polyclonal antibody detecting KCNB1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human KCNB1/Kv2.1 (Glu19-Val186).

Cible

DRK1, Delayed rectifier potassium channel 1, KCNB1, Potassium voltage-gated channel subfamily B member 1, Voltage-gated potassium channel subunit Kv2.1, h-DRK1

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q14721

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Potassium voltage-gated channel subfamily B member 1 (KCNB1/Kv2.1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

1. Li, XN. et al. (2013) The Journal of pharmacology and experimental therapeutics 344, 407-16. PMID: 23161216

2. Shepard, AR. et al. (1999) The American journal of physiology 277, C412-24. PMID: 10484328

3. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340

4. Ikeda, SR. et al. (1992) Pflugers Archiv : European journal of physiology 422, 201-3. PMID: 1283219

5. Mederos Y Schnitzler, M. et al. (2009) The Journal of biological chemistry 284, 4695-704. PMID: 19074135

6. Bocksteins, E. et al. (2009) The Journal of biological chemistry 284, 31625-34. PMID: 19717558

7. Bocksteins, E. et al. (2014) PloS one 9, e98960. PMID: 24901643

8. Albrecht, B. et al. (1993) Receptors & channels 1, 99-110. PMID: 8081723

9. Sano, Y. et al. (2002) FEBS letters 512, 230-4. PMID: 11852086

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human KCNB1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human KCNB1 Polyclonal Antibody (HC581014)

Aperçu

Images

Reférences

Fiche technique

SDS