Anti-Human KCNH2/ERG1 Recombinant Antibody (SAA1814) (HC535013)

Name: Anti-Human KCNH2/ERG1 Recombinant Antibody (SAA1814)
Brand: abinScience
SKU: HC535013
Price: 196 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC535013

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1814

Cible

H-ERG, ERG, HERG, hERG1, hERG-1, Potassium voltage-gated channel subfamily H member 2, ERG-1, KCNH2, Eag homolog, ERG1, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related protein 1

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q12809

RRID

Anti-Human KCNH2/ERG1 Antibody (SAA1814) (abinScience Cat# HC535013, RRID:AB_3727576)
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Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Voltage-gated inwardly rectifying potassium channel KCNH2 (ERG1) is a ~126 kDa protein. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity.

1. Abbott, GW. et al. (1999) Cell 97, 175-87. PMID: 10219239

2. Kagan, A. et al. (2000) The Journal of biological chemistry 275, 11241-8. PMID: 10753933

3. Paulussen, A. et al. (2000) Human mutation 15, 483. PMID: 10790218

4. Cui, J. et al. (2000) Current biology : CB 10, 671-4. PMID: 10837251

5. Yang, P. et al. (2002) Circulation 105, 1943-8. PMID: 11997281

6. Gong, Q. et al. (2002) American journal of physiology. Heart and circulatory physiology 283, H77-84. PMID: 12063277

7. Guasti, L. et al. (2008) Molecular and cellular biology 28, 5043-60. PMID: 18559421

8. Aidery, P. et al. (2012) Biochemical and biophysical research communications 418, 830-5. PMID: 22314138

9. Ng, CA. et al. (2012) PloS one 7, e31640. PMID: 22359612

10. Kang, Y. et al. (2015) The Biochemical journal 472, 71-82. PMID: 26363003

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human KCNH2/ERG1 Antibody (SAA1814)

Reférences

Fiche technique

Anti-Human KCNH2/ERG1 Recombinant Antibody (SAA1814).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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