中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC667014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human LBR Polyclonal Antibody (HC667014) is a rabbit polyclonal antibody detecting LBR in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
|
||||||||
| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human LBR (Ala7-Arg61). | ||||||||
| ターゲット | LMN2R, LBR, C14SR, Integral nuclear envelope inner membrane protein, Sterol C14-reductase, 3-beta-hydroxysterol Delta (14)-reductase, Delta(14)-sterol reductase LBR, Lamin-B receptor, Delta-14-SR, C-14 sterol reductase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14739 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Delta(14)-sterol reductase LBR is a ~70 kDa protein. Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane. 1. Waterham, HR. et al. (2003) American journal of human genetics 72, 1013-7. PMID: 12618959 2. Bennati, AM. et al. (2006) Biochimica et biophysica acta 1761, 677-85. PMID: 16784888 3. Clayton, P. et al. (2010) Nucleus (Austin, Tex.) 1, 354-66. PMID: 21327084 4. Tsai, PL. et al. (2016) eLife 5. PMID: 27336722 5. Silve, S. et al. (1998) Biochimica et biophysica acta 1392, 233-44. PMID: 9630650 6. Duband-Goulet, I. et al. (2000) Biochemistry 39, 6483-8. PMID: 10828963 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
