

| Numéro de catalogue | HV980033 | ||||
|---|---|---|---|---|---|
| Description |
Anti-Human LGR4 Nanobody (SAA2296) [SAA2296] (HV980033) is a alpaca monoclonal antibody detecting LGR4 in ELISA. Suitable for Human.
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| Reactivité des espèces | Human | ||||
| Applications | ELISA | ||||
| Espèce hôte | Alpaca | ||||
| Clonalité | Monoclonal | ||||
| Isotype | VHH-His | ||||
| ID de clone | SAA2296 | ||||
| Cible | G-protein coupled receptor 48, GPR48, LGR4, Leucine-rich repeat-containing G-protein coupled receptor 4 | ||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||
| Pureté | >95% as determined by SDS-PAGE. | ||||
| Purification | Purified by Nickel column. | ||||
| Numéro d'accès | Q9BXB1 | ||||
| Forme | Liquid | ||||
| Tampon de stockage | 0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Contexte | Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) is a ~104 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. | ||||
| Note | For research use only |

SDS-PAGE for Anti-Human LGR4 Nanobody (SAA2296)




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