Anti-Human LOXL2 Recombinant Antibody (SAA0169), APC (HP610137)

Name: Anti-Human LOXL2 Recombinant Antibody (SAA0169), APC
Brand: abinScience
SKU: HP610137
Price: 290 USD
Availability: InStock

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Numéro de catalogue	HP610137
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG4, kappa
ID de clone	SAA0169
Conjugaison	APC
Cible	LOXL2, Lysyl oxidase-related protein WS9-14, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC
Numéro d'accès	Q9Y4K0
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Lysyl oxidase homolog 2 (LOXL2) is a ~86 kDa protein. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. 1. Herranz, N. et al. (2016) The FEBS journal 283, 4263-4273. PMID: 27735137 2. Iturbide, A. et al. (2015) Molecular cell 58, 755-66. PMID: 25959397 3. Peinado, H. et al. (2005) The EMBO journal 24, 3446-58. PMID: 16096638 4. Cuevas, EP. et al. (2014) Biology open 3, 129-37. PMID: 24414204 5. Millanes-Romero, A. et al. (2013) Molecular cell 52, 746-57. PMID: 24239292 6. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human LOXL2 Recombinant Antibody (SAA0169), APC.pdf

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