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| カタログ番号 | HP610117 |
|---|---|
| 種反応性 | Human |
| アプリケーション | FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG4, kappa |
| クローンID | SAA0169 |
| 抱合 | FITC |
| ターゲット | LOXL2, Lysyl oxidase-related protein WS9-14, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), FITC |
| アクセッション番号 | Q9Y4K0 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | Lysyl oxidase homolog 2 (LOXL2) is a ~86 kDa protein. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2. 1. Herranz, N. et al. (2016) The FEBS journal 283, 4263-4273. PMID: 27735137 2. Iturbide, A. et al. (2015) Molecular cell 58, 755-66. PMID: 25959397 3. Peinado, H. et al. (2005) The EMBO journal 24, 3446-58. PMID: 16096638 4. Cuevas, EP. et al. (2014) Biology open 3, 129-37. PMID: 24414204 5. Millanes-Romero, A. et al. (2013) Molecular cell 52, 746-57. PMID: 24239292 6. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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