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Anti-Human Lysyl Oxidase Homolog 2/LOXL2 Recombinant Antibody (SAA2215) (HP610013)

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Anti-Human Lysyl Oxidase Homolog 2/LOXL2 Recombinant Antibody (SAA2215)
Anti-Human Lysyl Oxidase Homolog 2/LOXL2 Recombinant Antibody (SAA2215)
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Vista general
Número de catálogoHP610013
Descripción
Anti-Human Lysyl Oxidase Homolog 2/LOXL2 Recombinant Antibody (SAA2215) (HP610013) is a mouse monoclonal antibody detecting Lysyl Oxidase Homolog 2/LOXL2 in ELISA, IF. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IF
Especie huéspedMouse
ClonalidadMonoclonal
IsotipoIgG2a, kappa
ID de clonSAA2215
Objetivo LOXL2, Lysyl oxidase-related protein WS9-14, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso Q9Y4K0
RRID Anti-Human LOXL2 Antibody (SAA2215) (abinScience Cat# HP610013, RRID:AB_3729708)
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:2000-1:20000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo

Lysyl oxidase homolog 2 (LOXL2) is a ~86 kDa protein. Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2.

1. Herranz, N. et al. (2016) The FEBS journal 283, 4263-4273. PMID: 27735137
2. Iturbide, A. et al. (2015) Molecular cell 58, 755-66. PMID: 25959397
3. Peinado, H. et al. (2005) The EMBO journal 24, 3446-58. PMID: 16096638
4. Cuevas, EP. et al. (2014) Biology open 3, 129-37. PMID: 24414204
5. Millanes-Romero, A. et al. (2013) Molecular cell 52, 746-57. PMID: 24239292
6. Cuevas, EP. et al. (2017) Scientific reports 7, 44988. PMID: 28332555
Nota For research use only.
Isotype Control Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)
Imágenes
  • Anti-Human Lysyl Oxidase Homolog 2/LOXL2 Recombinant Antibody (SAA2215)

    SDS-PAGE

    SDS-PAGE for Anti-Human LOXL2 Antibody (SAA2215)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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