Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

Name: Anti-Human LRP5 Recombinant Antibody (SAA1526)
Brand: abinScience
SKU: HF797023
Price: 196 USD
Availability: InStock

Fiche technique Partager le produit Copier les informations

Prix(USD) :

Spécification :

50ug
100ug
1mg

Nombre :

Contactez-nous

Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HF797023

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA1526

Cible

Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

O75197

RRID

Anti-Human LRP5 Antibody (SAA1526) (abinScience Cat# HF797023, RRID:AB_3727287)

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs.

1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703

2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771

3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191

4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503

5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424

6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human LRP5 Antibody (SAA1526)

Reférences

Fiche technique

Anti-Human LRP5 Recombinant Antibody (SAA1526).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai