Human LRP5 Recombinant Protein (N-His) (HF797022)

Name: Human LRP5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HF797022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HF797022
Description	Recombinant Human LRP5 Protein, N-His (HF797022) expressed in E. coli, spanning Glu644-Gln1263. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O75197
Protein length	Glu644-Gln1263
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	72.20 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	LR3, LRP-5, LRP-7, LRP5, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 7
Background	Low-density lipoprotein receptor-related protein 5 is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs. 1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191 4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424 6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235
Note	For research use only