Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

Name: Anti-Human LRP5 Recombinant Antibody (SAA1526)
Brand: abinScience
SKU: HF797023
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF797023

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1526

Clonality

Monoclonal

Target

Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O75197

RRID

Anti-Human LRP5 Antibody (SAA1526) (abinScience Cat# HF797023, RRID:AB_3727287)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs.

1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703

2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771

3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191

4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503

5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424

6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human LRP5 Antibody (SAA1526)

References

Datasheet

Anti-Human LRP5 Recombinant Antibody (SAA1526).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

Overview

Images

References

Datasheet

SDS

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