Anti-Human LRP5 Recombinant Antibody (SAA1526) (HF797023)

Name: Anti-Human LRP5 Recombinant Antibody (SAA1526)
Brand: abinScience
SKU: HF797023
Price: 196 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HF797023

Реактивность видов

Human

Применения

ELISA

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG2a, kappa

ID клона

SAA1526

Цель

Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

O75197

RRID

Anti-Human LRP5 Antibody (SAA1526) (abinScience Cat# HF797023, RRID:AB_3727287)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

Low-density lipoprotein receptor-related protein 5 (LRP5) is a ~179 kDa protein. Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs.

1. Mao, J. et al. (2001) Molecular cell 7, 801-9. PMID: 11336703

2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771

3. Gong, Y. et al. (2001) Cell 107, 513-23. PMID: 11719191

4. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503

5. Semënov, M. et al. (2005) The Journal of biological chemistry 280, 26770-5. PMID: 15908424

6. Ai, M. et al. (2005) American journal of human genetics 77, 741-53. PMID: 16252235

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human LRP5 Antibody (SAA1526)

Ссылки

Даташит

Anti-Human LRP5 Recombinant Antibody (SAA1526).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа