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| カタログ番号 | HC410013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1797 | ||||
| ターゲット | Transforming growth factor beta-1-binding protein 1, Latent-transforming growth factor beta-binding protein 1, LTBP-1, LTBP1, TGF-beta1-BP-1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q14766 | ||||
| RRID | Anti-Human LTBP1 Antibody (SAA1797) (abinScience Cat# HC410013, RRID:AB_3727559) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Latent-transforming growth factor beta-binding protein 1 (LTBP1) is a ~186 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. 1. Miyazono, K. et al. (1991) The EMBO journal 10, 1091-101. PMID: 2022183 2. Saharinen, J. et al. (1996) The EMBO journal 15, 245-53. PMID: 8617200 3. Gleizes, PE. et al. (1996) The Journal of biological chemistry 271, 29891-6. PMID: 8939931 4. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 5. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human LTBP1 Antibody (SAA1797)
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