Human LTBP1 Recombinant Protein (N-His) (HC410012)

Name: Human LTBP1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC410012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC410012
Description	Recombinant Human LTBP1 Protein, N-His (HC410012) expressed in E. coli, spanning Glu876-Asp1315. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q14766
Protein length	Glu876-Asp1315
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	50.40 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	LTBP-1, LTBP1, Latent-transforming growth factor beta-binding protein 1, TGF-beta1-BP-1, Transforming growth factor beta-1-binding protein 1
Background	Latent-transforming growth factor beta-binding protein 1 is a ~186 kDa protein. Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. 1. Miyazono, K. et al. (1991) The EMBO journal 10, 1091-101. PMID: 2022183 2. Saharinen, J. et al. (1996) The EMBO journal 15, 245-53. PMID: 8617200 3. Gleizes, PE. et al. (1996) The Journal of biological chemistry 271, 29891-6. PMID: 8939931 4. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 5. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742
Note	For research use only

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Datasheet

Human LTBP1 Recombinant Protein (N-His).pdf

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Human LTBP1 Recombinant Protein (N-His) (HC410012)

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