Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

Name: Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161)
Brand: abinScience
SKU: HC694013
Price: 191 USD
Availability: InStock

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1mg

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Vista general

Número de catálogo	HC694013
Reactividad de especies	Human
Aplicaciones	IF
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	SAA2161
Objetivo	Mitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, MAD2
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q13257
RRID	Anti-Human MAD2L1/MAD2 Antibody (SAA2161) (abinScience Cat# HC694013, RRID:AB_3729531)
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a ~23 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. 1. Luo, X. et al. (2004) Nature structural & molecular biology 11, 338-45. PMID: 15024386 2. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 3. Luo, X. et al. (2000) Nature structural biology 7, 224-9. PMID: 10700282 4. Luo, X. et al. (2002) Molecular cell 9, 59-71. PMID: 11804586
Nota	For research use only.

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SDS-PAGE

SDS-PAGE for Anti-Human MAD2L1/MAD2 Antibody (SAA2161)

Referencias

Datasheet

Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161).pdf

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Formula

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