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Anti-Human MAD2L1 Polyclonal Antibody (HC694014)

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Overview
Catalog No.HC694014
Description
Anti-Human MAD2L1 Polyclonal Antibody (HC694014) is a rabbit polyclonal antibody detecting MAD2L1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human MAD2L1 (Met1-Asp205).
Target MAD2L1, Mitotic arrest deficient 2-like protein 1, HsMAD2, MAD2-like protein 1, Mitotic spindle assembly checkpoint protein MAD2A, MAD2
Purification Purified by antigen affinity column.
Accession Q13257
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a ~23 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

1. Luo, X. et al. (2004) Nature structural & molecular biology 11, 338-45. PMID: 15024386
2. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720
3. Luo, X. et al. (2000) Nature structural biology 7, 224-9. PMID: 10700282
4. Luo, X. et al. (2002) Molecular cell 9, 59-71. PMID: 11804586
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human MAD2L1 Polyclonal Antibody

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