Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

Name: Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161)
Brand: abinScience
SKU: HC694013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HC694013
Species reactivity	Human
Applications	IF
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG2a, kappa
Clone ID	SAA2161
Target	Mitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, MAD2
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q13257
RRID	Anti-Human MAD2L1/MAD2 Antibody (SAA2161) (abinScience Cat# HC694013, RRID:AB_3729531)
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a ~23 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. 1. Luo, X. et al. (2004) Nature structural & molecular biology 11, 338-45. PMID: 15024386 2. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 3. Luo, X. et al. (2000) Nature structural biology 7, 224-9. PMID: 10700282 4. Luo, X. et al. (2002) Molecular cell 9, 59-71. PMID: 11804586
Note	For research use only.

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SDS-PAGE for Anti-Human MAD2L1/MAD2 Antibody (SAA2161)

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Datasheet

Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161).pdf

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Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

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