Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161) (HC694013)

Name: Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161)
Brand: abinScience
SKU: HC694013
Price: 191 USD
Availability: InStock

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1mg

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Каталожный номер	HC694013
Реактивность видов	Human
Применения	IF
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	SAA2161
Цель	Mitotic spindle assembly checkpoint protein MAD2A, HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, MAD2
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q13257
RRID	Anti-Human MAD2L1/MAD2 Antibody (SAA2161) (abinScience Cat# HC694013, RRID:AB_3729531)
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Фон	Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) is a ~23 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. 1. Luo, X. et al. (2004) Nature structural & molecular biology 11, 338-45. PMID: 15024386 2. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 3. Luo, X. et al. (2000) Nature structural biology 7, 224-9. PMID: 10700282 4. Luo, X. et al. (2002) Molecular cell 9, 59-71. PMID: 11804586
Примечание	For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human MAD2L1/MAD2 Antibody (SAA2161)

Ссылки

Даташит

Anti-Human MAD2L1/MAD2 Recombinant Antibody (SAA2161).pdf

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