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| カタログ番号 | HW297014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MAGEA6 Polyclonal Antibody (HW297014) is a rabbit polyclonal antibody detecting MAGEA6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MAGEA6 (Ser96-Glu314). | ||||||||
| ターゲット | MAGEA6, Cancer/testis antigen 1.6, MAGE6, MAGE3B antigen, MAGE-6 antigen, CT1.6, Melanoma-associated antigen 6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43360 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Melanoma-associated antigen 6 (MAGEA6) is a ~34 kDa protein. Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. 1. Yang, B. et al. (2007) Cancer research 67, 9954-62. PMID: 17942928 2. Doyle, JM. et al. (2010) Molecular cell 39, 963-74. PMID: 20864041 3. Ravichandran, R. et al. (2019) EMBO reports 20, e47352. PMID: 31267705 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-MAGEA6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse testis lysate
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