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| カタログ番号 | HW326014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MATR3 (Lys478-Val576). | ||||||||
| ターゲット | Matrin-3, KIAA0723, MATR3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P43243 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Matrin-3 (MATR3) is a ~94 kDa protein. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins. 1. Morchikh, M. et al. (2017) Molecular cell 67, 387-399.e5. PMID: 28712728 2. Zhu, S. et al. (2020) Nature communications 11, 1685. PMID: 32245947 3. Treiber, T. et al. (2017) Molecular cell 66, 270-284.e13. PMID: 28431233 | ||||||||
| 注意事項 | For research use only. |
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