Anti-Human MBL-2 Polyclonal Antibody (HY274014)

Name: Anti-Human MBL-2 Polyclonal Antibody
Brand: abinScience
SKU: HY274014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HY274014

Description

Anti-Human MBL-2 Polyclonal Antibody (HY274014) is a rabbit polyclonal antibody detecting MBL-2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MBL2/MBP-C (Gly131-Ile248).

Cible

COLEC1, Mannose-binding protein C, MBL2, Mannan-binding protein, MBP1, Mannose-binding lectin, MBL, Collectin-1, MBP-C

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

P11226

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Mannose-binding protein C (MBL2/MBP-C) is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA.

1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269

2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085

3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089

4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411

5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758

6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429

7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295

8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human MBL-2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human MBL-2 Polyclonal Antibody (HY274014)

Aperçu

Images

Reférences

Fiche technique

SDS