Human MBL2 Recombinant Protein (N-His) (HY274042)

Name: Human MBL2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY274042
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HY274042
Description	Recombinant Human MBL2 Protein, N-His (HY274042) expressed in E. coli, spanning Gly131-Ile248. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P11226
Protein length	Gly131-Ile248
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	15.25 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	COLEC1, Collectin-1, MBL, MBL2, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
Background	Mannose-binding protein C is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA. 1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269 2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089 4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758 6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429 7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295 8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342
Note	For research use only