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| カタログ番号 | HY274014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MBL-2 Polyclonal Antibody (HY274014) is a rabbit polyclonal antibody detecting MBL-2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MBL2/MBP-C (Gly131-Ile248). | ||||||||
| ターゲット | COLEC1, Mannose-binding protein C, MBL2, Mannan-binding protein, MBP1, Mannose-binding lectin, MBL, Collectin-1, MBP-C | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P11226 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mannose-binding protein C (MBL2/MBP-C) is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA. 1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269 2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089 4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758 6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429 7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295 8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342 | ||||||||
| 注意事項 | For research use only. |
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