Anti-Human MBL-2 Polyclonal Antibody (HY274014)

Name: Anti-Human MBL-2 Polyclonal Antibody
Brand: abinScience
SKU: HY274014
Price: 168 USD
Availability: InStock

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100ug

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SDS

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Каталожный номер

HY274014

Описание

Anti-Human MBL-2 Polyclonal Antibody (HY274014) is a rabbit polyclonal antibody detecting MBL-2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human MBL2/MBP-C (Gly131-Ile248).

Цель

COLEC1, Mannose-binding protein C, MBL2, Mannan-binding protein, MBP1, Mannose-binding lectin, MBL, Collectin-1, MBP-C

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

P11226

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Mannose-binding protein C (MBL2/MBP-C) is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA.

1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269

2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085

3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089

4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411

5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758

6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429

7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295

8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human MBL-2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human MBL-2 Polyclonal Antibody (HY274014)

Обзор

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