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Anti-Human MCM3AP Polyclonal Antibody (HD528014)

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Aperçu
Numéro de catalogueHD528014
Description
Anti-Human MCM3AP Polyclonal Antibody (HD528014) is a rabbit polyclonal antibody detecting MCM3AP. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human MCM3AP (Thr602-Gly969).
Cible 80 kDa MCM3-associated protein, EC:2.3.1.-, EC:2.3.1.48, GANP, Germinal-center associated nuclear protein, KIAA0572, MAP80, MCM3 acetylating protein, MCM3 acetyltransferase, MCM3AP
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O60318
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Germinal-center associated nuclear protein (MCM3AP) is a ~218 kDa protein. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.

1. Wickramasinghe, VO. et al. (2010) Current biology : CB 20, 25-31. PMID: 20005110
2. Okamoto, N. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 471-84. PMID: 20384790
3. Jani, D. et al. (2012) Nucleic acids research 40, 4562-73. PMID: 22307388
4. Umlauf, D. et al. (2013) Journal of cell science 126, 2656-67. PMID: 23591820
5. Singh, SK. et al. (2013) Nature communications 4, 1830. PMID: 23652018
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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