Human MCM3AP Recombinant Protein (N-His) (HD528012)

Name: Human MCM3AP Recombinant Protein (N-His)
Brand: abinScience
SKU: HD528012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD528012
Description	Recombinant Human MCM3AP Protein, N-His (HD528012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O60318
Protein length	Thr602-Gly969
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	80 kDa MCM3-associated protein, EC:2.3.1.-, EC:2.3.1.48, GANP, Germinal-center associated nuclear protein, KIAA0572, MAP80, MCM3 acetylating protein, MCM3 acetyltransferase, MCM3AP
Background	Germinal-center associated nuclear protein is a ~218 kDa protein. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. 1. Wickramasinghe, VO. et al. (2010) Current biology : CB 20, 25-31. PMID: 20005110 2. Okamoto, N. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 471-84. PMID: 20384790 3. Jani, D. et al. (2012) Nucleic acids research 40, 4562-73. PMID: 22307388 4. Umlauf, D. et al. (2013) Journal of cell science 126, 2656-67. PMID: 23591820 5. Singh, SK. et al. (2013) Nature communications 4, 1830. PMID: 23652018
Note	For research use only

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Datasheet

Human MCM3AP Recombinant Protein (N-His).pdf

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Human MCM3AP Recombinant Protein (N-His) (HD528012)

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