Anti-Human MCM3AP Polyclonal Antibody (HD528014)

Name: Anti-Human MCM3AP Polyclonal Antibody
Brand: abinScience
SKU: HD528014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HD528014

Description

Anti-Human MCM3AP Polyclonal Antibody (HD528014) is a rabbit polyclonal antibody detecting MCM3AP. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MCM3AP (Thr602-Gly969).

Target

80 kDa MCM3-associated protein, EC:2.3.1.-, EC:2.3.1.48, GANP, Germinal-center associated nuclear protein, KIAA0572, MAP80, MCM3 acetylating protein, MCM3 acetyltransferase, MCM3AP

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O60318

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Germinal-center associated nuclear protein (MCM3AP) is a ~218 kDa protein. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.

1. Wickramasinghe, VO. et al. (2010) Current biology : CB 20, 25-31. PMID: 20005110

2. Okamoto, N. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 471-84. PMID: 20384790

3. Jani, D. et al. (2012) Nucleic acids research 40, 4562-73. PMID: 22307388

4. Umlauf, D. et al. (2013) Journal of cell science 126, 2656-67. PMID: 23591820

5. Singh, SK. et al. (2013) Nature communications 4, 1830. PMID: 23652018

Note

For research use only

Images

References

Datasheet

Anti-Human MCM3AP Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human MCM3AP Polyclonal Antibody (HD528014)

Overview

Images

References

Datasheet

SDS

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