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| カタログ番号 | HB964014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MDK Polyclonal Antibody (HB964014) is a rabbit polyclonal antibody detecting MDK. Suitable for Rat and Human.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MDK (Val21-Asp143). | ||||||||
| ターゲット | ARAP, Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, Midkine, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P21741 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Midkine (MDK) is a ~15 kDa protein. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression. 1. Maeda, N. et al. (1999) The Journal of biological chemistry 274, 12474-9. PMID: 10212223 2. Muramatsu, H. et al. (2000) Biochemical and biophysical research communications 270, 936-41. PMID: 10772929 3. Kurosawa, N. et al. (2001) Glycoconjugate journal 18, 499-507. PMID: 12084985 4. Stoica, GE. et al. (2002) The Journal of biological chemistry 277, 35990-8. PMID: 12122009 5. Sakaguchi, N. et al. (2003) Neuroscience research 45, 219-24. PMID: 12573468 6. Muramatsu, H. et al. (2004) Journal of cell science 117, 5405-15. PMID: 15466886 7. Huang, Y. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1613-22. PMID: 18469519 8. Weckbach, LT. et al. (2014) Blood 123, 1887-96. PMID: 24458438 9. Horiba, M. et al. (2000) The Journal of clinical investigation 105, 489-95. PMID: 10683378 | ||||||||
| 注意事項 | For research use only |
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