Anti-Human MDK/Midkine Recombinant Antibody (SAA1776) (HB964013)

Name: Anti-Human MDK/Midkine Recombinant Antibody (SAA1776)
Brand: abinScience
SKU: HB964013
Price: 110 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB964013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1776

Clonality

Monoclonal

Target

Amphiregulin-associated protein, Midgestation and kidney protein, NEGF2, MDK, ARAP, MK1, Neurite outgrowth-promoting factor 2, MK, Midkine, Neurite outgrowth-promoting protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P21741

RRID

Anti-Human MDK/Midkine Antibody (SAA1776) (abinScience Cat# HB964013, RRID:AB_3727538)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Midkine (MDK) is a ~15 kDa protein. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression.

1. Maeda, N. et al. (1999) The Journal of biological chemistry 274, 12474-9. PMID: 10212223

2. Muramatsu, H. et al. (2000) Biochemical and biophysical research communications 270, 936-41. PMID: 10772929

3. Kurosawa, N. et al. (2001) Glycoconjugate journal 18, 499-507. PMID: 12084985

4. Stoica, GE. et al. (2002) The Journal of biological chemistry 277, 35990-8. PMID: 12122009

5. Sakaguchi, N. et al. (2003) Neuroscience research 45, 219-24. PMID: 12573468

6. Muramatsu, H. et al. (2004) Journal of cell science 117, 5405-15. PMID: 15466886

7. Huang, Y. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1613-22. PMID: 18469519

8. Weckbach, LT. et al. (2014) Blood 123, 1887-96. PMID: 24458438

9. Horiba, M. et al. (2000) The Journal of clinical investigation 105, 489-95. PMID: 10683378

Note

For research use only.

Isotype Control

Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

Images

SDS-PAGE

SDS-PAGE for Anti-Human MDK/Midkine Antibody (SAA1776)

References

Datasheet

Anti-Human MDK/Midkine Recombinant Antibody (SAA1776).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human MDK/Midkine Recombinant Antibody (SAA1776) (HB964013)

Overview

Images

References

Datasheet

SDS

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