Anti-Human MDK Polyclonal Antibody (HB964014)

Name: Anti-Human MDK Polyclonal Antibody
Brand: abinScience
SKU: HB964014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB964014

Description

Anti-Human MDK Polyclonal Antibody (HB964014) is a rabbit polyclonal antibody detecting MDK. Suitable for Rat and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MDK (Val21-Asp143).

Target

ARAP, Amphiregulin-associated protein, MDK, MK, MK1, Midgestation and kidney protein, Midkine, NEGF2, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P21741

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Midkine (MDK) is a ~15 kDa protein. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression.

1. Maeda, N. et al. (1999) The Journal of biological chemistry 274, 12474-9. PMID: 10212223

2. Muramatsu, H. et al. (2000) Biochemical and biophysical research communications 270, 936-41. PMID: 10772929

3. Kurosawa, N. et al. (2001) Glycoconjugate journal 18, 499-507. PMID: 12084985

4. Stoica, GE. et al. (2002) The Journal of biological chemistry 277, 35990-8. PMID: 12122009

5. Sakaguchi, N. et al. (2003) Neuroscience research 45, 219-24. PMID: 12573468

6. Muramatsu, H. et al. (2004) Journal of cell science 117, 5405-15. PMID: 15466886

7. Huang, Y. et al. (2008) Cell cycle (Georgetown, Tex.) 7, 1613-22. PMID: 18469519

8. Weckbach, LT. et al. (2014) Blood 123, 1887-96. PMID: 24458438

9. Horiba, M. et al. (2000) The Journal of clinical investigation 105, 489-95. PMID: 10683378

Note

For research use only

Images

References

Datasheet

Anti-Human MDK Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human MDK Polyclonal Antibody (HB964014)

Overview

Images

References

Datasheet

SDS

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