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| カタログ番号 | HB572014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MEFV Polyclonal Antibody (HB572014) is a rabbit polyclonal antibody detecting Pyrin; Marenostrin; MEFV; MEF; TRIM20 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human MEFV (Glu589-Asp781). | ||||||||
| ターゲット | Pyrin; Marenostrin; MEFV; MEF; TRIM20 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15553 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Pyrin (MEFV) is a ~86 kDa protein. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production. Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection. 1. Centola, M. et al. (2000) Blood 95, 3223-31. PMID: 10807793 2. Mansfield, E. et al. (2001) Blood 98, 851-9. PMID: 11468188 3. Yu, JW. et al. (2006) Cell death and differentiation 13, 236-49. PMID: 16037825 4. Chae, JJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9982-7. PMID: 16785446 5. Papin, S. et al. (2007) Cell death and differentiation 14, 1457-66. PMID: 17431422 6. Yu, JW. et al. (2007) Molecular cell 28, 214-27. PMID: 17964261 7. Chae, JJ. et al. (2008) Blood 112, 1794-803. PMID: 18577712 8. Waite, AL. et al. (2009) Experimental biology and medicine (Maywood, N.J.) 234, 40-52. PMID: 19109554 9. Waite, AL. et al. (2009) PloS one 4, e6147. PMID: 19584923 10. Kimura, T. et al. (2015) The Journal of cell biology 210, 973-89. PMID: 26347139 | ||||||||
| 注意事項 | For research use only |
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