Anti-Human HGFR/c-MET Recombinant Antibody (SAA0111), PerCP (HY196147)

Name: Anti-Human HGFR/c-MET Recombinant Antibody (SAA0111), PerCP
Brand: abinScience
SKU: HY196147
Price: 268 USD
Availability: InStock

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概要

カタログ番号	HY196147
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4, kappa
クローンID	SAA0111
抱合	PerCP
ターゲット	Tyrosine-protein kinase Met, Hepatocyte growth factor receptor, Proto-oncogene c-Met, Scatter factor receptor, HGF receptor, SF receptor, HGF/SF receptor, MET
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PerCP
アクセッション番号	P08581
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	Hepatocyte growth factor receptor (MET/HGFR) is a ~155 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. MET is the therapeutic target of amivantamab (Rybrevant).
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.