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Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO) (HY196016)

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Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)

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Spec:

100ug
1mg

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References
Datasheet
SDS

Overview

Catalog No.	HY196016
Description	Emibetuzumab (HY196016) is a research-grade recombinant antibody targeting Tyrosine-protein kinase Met. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Humanized
Isotype	IgG4-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Tyrosine-protein kinase Met, Hepatocyte growth factor receptor, Proto-oncogene c-Met, Scatter factor receptor, HGF receptor, SF receptor, HGF/SF receptor, MET
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P08581
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	LA480, LY-2875358, 1365287-97-3
Background	Hepatocyte growth factor receptor (MET/HGFR) is a ~155 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. MET is the therapeutic target of amivantamab (Rybrevant).
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Emibetuzumab.
Bioactivity

Detects MET/c-Met/HGFR in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Emibetuzumab.
Western blot

Western blot analysis was performed using anti-MET/c-Met/HGFR monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human MET/c-Met/HGFR (Catalog No: HY196011)
Lane 2: negative control

References

Datasheet

Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO).pdf

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Anti-Human HGFR/c-MET Reference Antibody (Emibetuzumab, RUO)