Anti-Human MICA Recombinant Antibody (16A8), APC (HS894137)

Name: Anti-Human MICA Recombinant Antibody (16A8), APC
Brand: abinScience
SKU: HS894137
Price: 214 USD
Availability: InStock

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Каталожный номер	HS894137
Реактивность видов	Human
Применения	FCM
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	16A8
Конъюгация	APC
Проверенные приложения	FCM
Цель	MICA, MIC-A, MHC class I polypeptide-related sequence A, PERB11.1
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), APC
Номер доступа	Q29983
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	MHC class I polypeptide-related sequence A (MICA) is a ~42 kDa protein. Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. 1. Steinle, A. et al. (2001) Immunogenetics 53, 279-87. PMID: 11491531 2. Sutherland, CL. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 671-9. PMID: 11777960 3. Bauer, S. et al. (1999) Science (New York, N.Y.) 285, 727-9. PMID: 10426993
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Flow cytometry

Flow-cytometry APC using anti-human MICA antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an APC anti-human MICA monoclonal antibody (Catalog HS894137) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

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