Anti-Human MICA/B Recombinant Antibody (SAA0346) (HS894207)

Name: Anti-Human MICA/B Recombinant Antibody (SAA0346)
Brand: abinScience
SKU: HS894207
Price: 191 USD
Availability: InStock

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Número de catálogo	HS894207
Reactividad de especies	Human
Aplicaciones	Blocking, ELISA, FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0346
Objetivo	MHC class I polypeptide-related sequence A, MIC-A, MICA, PERB11.1, MHC class I polypeptide-related sequence B, MIC-B, MICB, PERB11.2
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q29983, Q29980
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	MHC class I polypeptide-related sequence A (MICA/MICB) is a ~42 kDa protein. Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. 1. Steinle, A. et al. (2001) Immunogenetics 53, 279-87. PMID: 11491531 2. Sutherland, CL. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 671-9. PMID: 11777960 3. Bauer, S. et al. (1999) Science (New York, N.Y.) 285, 727-9. PMID: 10426993
Nota	For research use only.