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| カタログ番号 | HY526013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1516 | ||||
| ターゲット | SL-1, Transin-1, MMP-3, MMP3, Matrix metalloproteinase-3, Stromelysin-1, STMY1 | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P08254 | ||||
| RRID | Anti-Human MMP3 Antibody (SAA1516) (abinScience Cat# HY526013, RRID:AB_3727277) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. 1. Arza, B. et al. (2000) European journal of biochemistry 267, 6378-84. PMID: 11029580 2. Ogata, Y. et al. (1992) The Journal of biological chemistry 267, 3581-4. PMID: 1371271 3. Nagase, H. et al. (1990) Biochemistry 29, 5783-9. PMID: 2383557 4. Shin, EJ. et al. (2012) Neurochemistry international 60, 249-56. PMID: 22265821 5. Choi, DH. et al. (2011) The Journal of biological chemistry 286, 14168-77. PMID: 21330369 6. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human MMP3 Antibody (SAA1516)
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