Anti-MMP3 Polyclonal Antibody (HY526014)

Name: Anti-MMP3 Polyclonal Antibody
Brand: abinScience
SKU: HY526014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY526014

Description

Anti-MMP3 Polyclonal Antibody (HY526014) is a rabbit polyclonal antibody detecting MMP3 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human MMP3 (Phe100-Cys477).

Target

SL-1, Transin-1, MMP-3, MMP3, Matrix metalloproteinase-3, Stromelysin-1, STMY1

Purification

Purified by antigen affinity column.

Accession

P08254

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage.

1. Arza, B. et al. (2000) European journal of biochemistry 267, 6378-84. PMID: 11029580

2. Ogata, Y. et al. (1992) The Journal of biological chemistry 267, 3581-4. PMID: 1371271

3. Nagase, H. et al. (1990) Biochemistry 29, 5783-9. PMID: 2383557

4. Shin, EJ. et al. (2012) Neurochemistry international 60, 249-56. PMID: 22265821

5. Choi, DH. et al. (2011) The Journal of biological chemistry 286, 14168-77. PMID: 21330369

6. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311

Note

For research use only.

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