Anti-Human MMP3 Recombinant Antibody (SAA1516) (HY526013)

Name: Anti-Human MMP3 Recombinant Antibody (SAA1516)
Brand: abinScience
SKU: HY526013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY526013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1516

Clonality

Monoclonal

Target

SL-1, Transin-1, MMP-3, MMP3, Matrix metalloproteinase-3, Stromelysin-1, STMY1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P08254

RRID

Anti-Human MMP3 Antibody (SAA1516) (abinScience Cat# HY526013, RRID:AB_3727277)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Stromelysin-1 (MMP3) is a ~53 kDa protein. Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage.

1. Arza, B. et al. (2000) European journal of biochemistry 267, 6378-84. PMID: 11029580

2. Ogata, Y. et al. (1992) The Journal of biological chemistry 267, 3581-4. PMID: 1371271

3. Nagase, H. et al. (1990) Biochemistry 29, 5783-9. PMID: 2383557

4. Shin, EJ. et al. (2012) Neurochemistry international 60, 249-56. PMID: 22265821

5. Choi, DH. et al. (2011) The Journal of biological chemistry 286, 14168-77. PMID: 21330369

6. Feng, T. et al. (2022) Antiviral research 206, 105388. PMID: 35940311

Note

For research use only.

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