Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025)

Name: Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726)
Brand: abinScience
SKU: HW551025
Price: 194 USD
Availability: InStock

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Número de catálogo	HW551025
Descripción	Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat. Highlights ●Multi-Species — Cross-reactive for translational research.
Reactividad de especies	Human, Mouse, Rat
Aplicaciones	ELISA, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2b
ID de clon	1A726
Inmunógeno	E. coli - derived recombinant rat GPX4 (Gly73-Leu196).
Objetivo	EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Peso molecular observado	20 kDa
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P36970
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735
Nota	For research use only

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Datasheet

Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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