Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A727) (HW551035)

Name: Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A727)
Brand: abinScience
SKU: HW551035
Price: 194 USD
Availability: InStock

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Overview

Catalog No.	HW551035
Description	Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A727) (HW551035) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat. Highlights ●Multi-Species — Cross-reactive for translational research.
Species reactivity	Human, Mouse, Rat
Applications	ELISA, WB, IF
Host species	Mouse
Isotype	IgG1
Clone ID	1A727
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant rat GPX4 (Gly73-Leu196).
Target	EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4
Endotoxin level	Please contact with the lab for this information.
Observed Molecular Weight	20 kDa
Purification	Protein A/G purified from cell culture supernatant.
Accession	P36970
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735
Note	For research use only

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Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A727).pdf

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Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A727) (HW551035)

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