Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025)

Name: Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726)
Brand: abinScience
SKU: HW551025
Price: 194 USD
Availability: InStock

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Numéro de catalogue	HW551025
Description	Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat. Highlights ●Multi-Species — Cross-reactive for translational research.
Reactivité des espèces	Human, Mouse, Rat
Applications	ELISA, WB
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2b
ID de clone	1A726
Immunogène	E. coli - derived recombinant rat GPX4 (Gly73-Leu196).
Cible	EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Masse moléculaire observée	20 kDa
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P36970
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735
Note	For research use only

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Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726).pdf

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