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| カタログ番号 | HW551025 |
|---|---|
| 説明 |
Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat.
Highlights
|
| 種反応性 | Human, Mouse, Rat |
| アプリケーション | ELISA, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2b |
| クローンID | 1A726 |
| 免疫原 | E. coli - derived recombinant rat GPX4 (Gly73-Leu196). |
| ターゲット | EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4 |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% as determined by SDS-PAGE. |
| 観測分子量 | 20 kDa |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P36970 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735 |
| 注意事項 | For research use only |
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