Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025)

Name: Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726)
Brand: abinScience
SKU: HW551025
Price: 194 USD
Availability: InStock

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Каталожный номер	HW551025
Описание	Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726) (HW551025) is a mouse monoclonal antibody detecting GPX4. Suitable for Human, Mouse, and Rat. Highlights ●Multi-Species — Cross-reactive for translational research.
Реактивность видов	Human, Mouse, Rat
Применения	ELISA, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2b
ID клона	1A726
Иммуноген	E. coli - derived recombinant rat GPX4 (Gly73-Leu196).
Цель	EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Наблюдаемая молекулярная масса	20 kDa
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P36970
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735
Примечание	For research use only

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Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody (1A726).pdf

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