Anti-Human MUSK Recombinant Antibody (ARGX-119) (HT224023)

Name: Anti-Human MUSK Recombinant Antibody (ARGX-119)
Brand: abinScience
SKU: HT224023
Price: 191 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT224023

Reactividad de especies

Human

Aplicaciones

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Clonalidad

Monoclonal

ID de clon

ARGX-119

Objetivo

EC:2.7.10.1, MUSK, MuSK, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O15146

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Muscle, skeletal receptor tyrosine-protein kinase (MUSK) is a ~97 kDa protein. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.

1. Tan-Sindhunata, MB. et al. (2015) European journal of human genetics : EJHG 23, 1151-7. PMID: 25537362

Nota

For research use only

Imágenes

Referencias

Datasheet