

| Каталожный номер | HX949014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NAP1L1 (Arg72-Glu356). | ||||||||
| Цель | NAP-1-related protein, NRP, hNRP, Nucleosome assembly protein 1-like 1, NAP1L1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P55209 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Nucleosome assembly protein 1-like 1 (NAP1L1) is a ~45 kDa protein. Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair. Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. 1. Okuwaki, M. et al. (2010) Genes to cells : devoted to molecular & cellular mechanisms 15, 13-27. PMID: 20002496 2. Mehrotra, PV. et al. (2011) Molecular cell 41, 46-55. PMID: 21211722 3. Ohtomo, H. et al. (2016) Genes to cells : devoted to molecular & cellular mechanisms 21, 252-63. PMID: 26841755 4. Lee, JY. et al. (2017) Nucleic acids research 45, 4696-4707. PMID: 28369616 5. Machida, S. et al. (2014) Scientific reports 4, 4863. PMID: 24798879 | ||||||||
| Примечание | For research use only. |
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