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| カタログ番号 | HD517014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NAPEPLD Polyclonal Antibody (HD517014) is a rabbit polyclonal antibody detecting NAPEPLD. Suitable for Human, Rat, and Mouse.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NAPEPLD (Ser76-Phe393). | ||||||||
| ターゲット | C7orf18, EC:3.1.4.54, N-acyl phosphatidylethanolamine phospholipase D, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, NAPE-PLD, NAPE-hydrolyzing phospholipase D, NAPEPLD | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6IQ20 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) is a ~45 kDa protein. D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain. May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. 1. Okamoto, Y. et al. (2004) The Journal of biological chemistry 279, 5298-305. PMID: 14634025 2. Wang, J. et al. (2006) The Journal of biological chemistry 281, 12325-35. PMID: 16527816 3. Magotti, P. et al. (2015) Structure (London, England : 1993) 23, 598-604. PMID: 25684574 4. Margheritis, E. et al. (2016) ACS chemical biology 11, 2908-2914. PMID: 27571266 | ||||||||
| 注意事項 | For research use only |
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