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| カタログ番号 | HT177013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | FCM, ICC, IF, IP, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | 9G3 | ||||
| ターゲット | Kinetochore protein NDC80 homolog, Highly expressed in cancer protein, Kinetochore protein Hec1, HsHec1, Kinetochore-associated protein 2, Retinoblastoma-associated protein HEC, NDC80, HEC, HEC1, KNTC2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O14777 | ||||
| RRID | Anti-Human NDC80/HEC1 Antibody (9G3) (abinScience Cat# HT177013, RRID:AB_3729529) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Kinetochore protein NDC80 homolog (HEC1) is a ~73 kDa protein. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. 1. Martin-Lluesma, S. et al. (2002) Science (New York, N.Y.) 297, 2267-70. PMID: 12351790 2. DeLuca, JG. et al. (2003) Current biology : CB 13, 2103-9. PMID: 14654001 3. Bharadwaj, R. et al. (2004) The Journal of biological chemistry 279, 13076-85. PMID: 14699129 4. Joseph, J. et al. (2004) Current biology : CB 14, 611-7. PMID: 15062103 5. Stucke, VM. et al. (2004) Chromosoma 113, 1-15. PMID: 15235793 6. Meraldi, P. et al. (2004) Developmental cell 7, 45-60. PMID: 15239953 7. DeLuca, JG. et al. (2005) Molecular biology of the cell 16, 519-31. PMID: 15548592 8. Lin, YT. et al. (2006) Oncogene 25, 6901-14. PMID: 16732327 9. Zhao, G. et al. (2019) The Journal of biological chemistry 294, 576-592. PMID: 30409912 10. Chen, Y. et al. (1997) Molecular and cellular biology 17, 6049-56. PMID: 9315664 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human NDC80/HEC1 Antibody (9G3)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
