

| Número de catálogo | HB121014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human NELFE Polyclonal Antibody (HB121014) is a rabbit polyclonal antibody detecting NELFE in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human NELFE (Gly261-Arg331). | ||||||||
| Objetivo | RDBP, RD, NELF-E, RNA-binding protein RD, NELFE, Negative elongation factor E | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | P18615 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Negative elongation factor E (NELFE) is a ~43 kDa protein. Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. 1. Yamaguchi, Y. et al. (1999) Cell 97, 41-51. PMID: 10199401 2. Gibson, BA. et al. (2016) Science (New York, N.Y.) 353, 45-50. PMID: 27256882 3. Yamaguchi, Y. et al. (2002) Molecular and cellular biology 22, 2918-27. PMID: 11940650 4. Narita, T. et al. (2003) Molecular and cellular biology 23, 1863-73. PMID: 12612062 5. Rao, JN. et al. (2008) Biochemistry 47, 3756-61. PMID: 18303858 6. Vos, SM. et al. (2016) eLife 5. PMID: 27282391 | ||||||||
| Nota | For research use only. |
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