Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038) (HP187015)

Name: Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038)
Brand: abinScience
SKU: HP187015
Price: 106 USD
Availability: InStock

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Número de catálogo	HP187015
Descripción	Anti-Human NEU3/Sialidase-3 Antibody (1A038) [1A038] (HP187015) is a mouse monoclonal antibody detecting NEU3 in ELISA, WB. Suitable for Human.
Reactividad de especies	Human
Aplicaciones	ELISA, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2b
ID de clon	1A038
Inmunógeno	Synthesized peptide.
Objetivo	Isoform 2 of Sialidase-3, 3.2.1.18, Ganglioside sialidasedis, Membrane sialidase, N-acetyl-alpha-neuraminidase 3, NEU3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q9UQ49
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Sialidase-3 (NEU3) is a ~48 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes. 1. Wada, T. et al. (1999) Biochemical and biophysical research communications 261, 21-7. PMID: 10405317 2. Monti, E. et al. (2000) The Biochemical journal 349, 343-51. PMID: 10861246 3. Wang, Y. et al. (2001) European journal of biochemistry 268, 2201-8. PMID: 11298736 4. Wang, Y. et al. (2002) The Journal of biological chemistry 277, 26252-9. PMID: 12011038 5. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605 6. Albohy, A. et al. (2010) Glycobiology 20, 1127-38. PMID: 20511247 7. Rodriguez-Walker, M. et al. (2017) Scientific reports 7, 4167. PMID: 28646141 8. Wada, T. et al. (2007) Oncogene 26, 2483-90. PMID: 17334392 9. Mozzi, A. et al. (2015) Glycobiology 25, 855-68. PMID: 25922362
Nota	For research use only.

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SDS-PAGE for Anti-Human NEU3/Sialidase-3 Antibody (1A038)

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Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038).pdf

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Anti-Human NEU3/Sialidase-3 Monoclonal Antibody (1A038) (HP187015)

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